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The Role of Nanotechnology in Cancer Therapy

 It’s not a new thing to mention that cancer is one of the leading causes of global deaths. Despite the research, treating patients with cancer is still an uphill battle. At present, chemotherapy and radiotherapy are two primary treatments suggested by healthcare professionals to destroy uncontrolled cell division. Although these treatment measures prove beneficial in countless cases, they also destroy healthy body cells and cancer cells. This eventually results in non-specific actions, including weakness, anemia, and loss of hair.  Since tumors’ pathological features are responsible for reducing the efficiency of standard cancer treatments, researchers are looking forward to RNA nanotechnology these days. The characteristics of nanoparticles, including smaller size and increased conjugate absorption, benefit the nanoscale vehicles, including magnetic nanoparticles, polymeric nanoparticles, liposomes, nanoshells, and dendrimers. The multifunctional characteristics of nanoparti...
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What You Must Know About RNA Transcription?

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Among the most important discoveries in science was really the discovery of DNA. A deeper understanding of the DNA structure has now shown the answers to all of our concerns.The medical experts describe DNA codes for proteins in three stages: replication, transcription, and translation. After DNA's two strands have been replicated, transcription is used to copy the details into RNA. After mRNA is produced, it goes through a series of post-transcriptional alterations to become mature mRNA, which would then be transferred from the nucleus to the cytoplasm, where ribosomes aid with protein synthesis. Steps in Transcription Initiation To continue, transcription factors look for certain nucleotide sequences in the DNA known as gene promoters. The promoter portion of the gene, which includes the transcription initiation site, is then bound by RNA polymerase. RNA polymerase unwinds DNA into single strands that can be used as a basis for the synthesis of mRNA. Elongation To construct the c...
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RNA Nanotechnology Is Offering Great Results For Cancer Therapy

Cases of cancer are rising throughout the world. Researchers, scientists, medical professionals all have been working hard to gain some headway in the direction of cancer treatment. Small interfering RNA have shown signs of promising results but getting them to their targets in cancer cells has proved rather difficult. Researchers have now discovered that by joining antibody-like RNA nanoparticles with microvesicles help render potent RNS therapeutics mainly to cancer cells. We can get ligand displaying exosomes by using RNA nanoparticle shaped like an arrow to display a ligand on the exosomes’ surface. Exosomes’ biodistribution improves when its surface is decorated with RNA nanoparticles that hold chemical ligands in contact with cancer cell surface makers. Earlier during the clinical trails, working with RNA agents posed a problem in which although these agents made their way into the cancer cells, they still remained ineffective as they got stuck in internal vesicles known as endo...
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Oligonucleotide Therapeutics Is Proving To Be A Vital Drug For Fatal Diseases

We think there is not a single person in this world at this moment who is not aware about the COVID-19 pandemic. The virus has wreaked havoc throughout the world and put a lot of pressure on the healthcare facilities. This has brought scientists from all corners of the world together to find a solution to this problem. A new type of drug, known as oligonucleotide therapeutic, is believed to be the solution to this virus. There are companies online that provide custom DNA oligos. The Oligonucleotide Therapeutics Society has been doing its best to spread the awareness about this new drug and what potential it possesses to fight with the COVID-19. The distinct thing about oligonucleotide therapeutics is that the technology used to create it is rather different from the ones that are used to develop traditional drugs. In the case of oligonucleotide therapeutics, the technologies target disease at the level of RNA. These are drugs are the first drugs that have received the nod from the sc...
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